两种胰岛素强化治疗方案对血糖控制不佳2型糖尿病的临床疗效和安全性比较

The clinical efficacy and safety of two kinds of insulin intensive treatment program for bad-controlled type 2 diabetes patient

目的探讨两种胰岛素强化治疗方案治疗血糖控制不佳2型糖尿病的临床效果及用药安全性。方法选取2010年3月～2011年2月本院门诊和住院部收治的2型糖尿病患者84例,随机分为对照组与观察组,分别采取诺和灵R+N和诺和锐30治疗。结果观察组治疗后空腹血糖(FPG)、餐后2h血糖(2hPG)和糖化血红蛋白(HbA1c)均明显降低(P<0.05),但组间比较差异无统计学意义(P>0.05);两组达标时间比较差异无统计学意义(P>0.05);观察组胰岛素用量明显少于对照组,差异有统计学意义(P<0.05);观察组低血糖发生率为4.76%,明显低于对照组(P<0.05)。结论诺和锐30治疗血糖控制不佳2型糖尿病疗效显著,可有效控制患者血糖水平,降低低血糖发生率,安全性高。

Objective To investigate the clinical effect and safety of two kinds of insulin intensive therapy regimens in the treatment of bad-controlled type 2 diabetes patients. Methods Eighty four cases of type 2 diabetes patients treated from March 2010 to February 2011 in our hospital outpatient and inpatient department, were randomly divided into control group and observation group, respectively took Novolin R＋N and insulin aspart 30 treatment. Results The FPG, 2hPG and HbAlc of observation group were decreased （P 〈 0.05）, but two groups were not significantly different （P 〉 0.05）; standard time comparison between two groups showed no significant difference （P 〉 0.05）; insulin dosage of ob- servation group were less than those of control group, the difference had statistics significance （P 〈 0.05）; hypoglycemia incidence rate of the observation group was 4.76%, which was significantly lower than that of the control group （P 〈 0.05）. Conclusion The clinical efficacy of insulin aspart 30 in treatment of bad-controlled type 2 diabetes patient were curative, it can effectively control the blood glucose level, and reduce the incidence of hypoglycemia, high security.