双歧杆菌三联活菌散辅助治疗新生儿黄疸的临床效果观察

Clinical effect observation of live combined bifidobacterium in treatment of neonatal jaundice

目的对双歧杆菌三联活菌散辅助治疗新生儿黄疸的临床效果进行观察分析。方法随机选取2010年2月～2011年2月于本院妇产科接受治疗的120例黄疸新生儿,将其平均分为两组,对照组60例患儿采用常规治疗方法进行治疗,包括蓝光照射和药物治疗,观察组患儿在常规治疗的基础上使用双歧杆菌三联活菌散辅助治疗,直至黄疸消失,对两组患儿治疗过程中黄疸指标进行观察比较。结果观察组的治疗总有效率为91.67%,显著高于对照组的68.33%,观察组患儿日均胆红素下降值和结束治疗所需时间均要显著好于对照组,上述各指标比较,差异均具有统计学意义(P<0.05);观察组和对照组的不良反应发生率分别为3.33%和8.33%,差异无统计学意义(P>0.05)。结论双歧杆菌三联活菌散辅助治疗新生儿黄疸的临床疗效明显,缩短了治疗时间,具有安全、见效快的特点,值得临床借鉴应用。

Objective To observe and analyze the clinical effect observation of neonatal jaundice adjuvant treated by live combined bifidobacterium. Methods One hundred and twenty cases of neonatal jaundice were selected from February 2010 to February 2011, who received treatment. They were averagely divided into two groups. Sixty cases of control group were treated by the conventional treatment, including blue light irradiation and drug treatment. Observa- tion group were taken live combined bifidobacterium as adjuvant therapy on the basis of conventional treatment until the jaundice disappeared. The jaundice index of both groups were observed and compared. Results Through the obser- vation, the effective rate of the observation group was 91.67%, which was significantly higher than the control group, which was 68.33%. The daily bilirubin drop value and end time for treatment of the observation group were signifi- cantly better than the control group, and the differences had statistical significance （P 〈 0.05）. The adverse reaction rate of observation group and control group were 3.33% and 8.33% respectively, the difference had no significance （P 〉 0.05）. Conclusion Live combined bifidobacterium has an obvious effect to neonatal jaundice. It can shorten the treat- ment time, with security and fast effect. It is worth clinical application.