重组组织型纤溶酶原激活剂治疗急性心肌梗死(附15例临床分析)

rt PA in the treatment of acute myocardial infarction (Clinical analysis of 15 cases)

目的 :观察急性心肌梗死 (AMI)患者应用重组组织型纤溶酶原激活剂 (rt- PA)进行静脉溶栓治疗疗效。方法 :动态观察 1 5例 AMI患者溶栓后 2 4h内的心电图、血清酶和临床症状的变化以及梗死后并发症发生率。结果 :临床判断 1 5例总再通率为 86 .7%。冠状动脉造影后证实 75 % (3/ 4)的患者梗死相关血管再通。溶栓过程中未见严重出血及其他副作用。结论 :rt- PA用于临床疗效较确切。总量 1 0 0 mg的疗效显著高于 5 0 mg。

Objective:The study was designed to evaluate efficiency of intravenous thrombolytic therapy with rt PA in acute myocardial infarction.Method:15 cases were observed continuously with ECG、serum enzyme、clinical symptoms and complicatons of infarction at 24 hours after thrombolysis therapy with rt PA.Result:The total rate of reperfusion was 86.7 % according to clinical evaluation,and 75% according to coronary angiography.Conclusion:Effect of rt PA in thrombolytic therapy was exact.100 mg of rt PA was better than 50 mg.