抗C1_q抗体与系统性红斑狼疮疾病活动及狼疮肾炎的关系

Relationship of Anti-C1_q Autoantibodies to Disease Activity and Lupus Nephritis in Systemic Lupus Erythematosus

目的探讨血清抗C1q抗体(C1qAb)与系统性红斑狼疮(SLE)疾病活动、狼疮肾炎(LN)的关系。方法应用酶联免疫吸附试验(ELISA)检测60例SLE患者(A组),40例非SLE的自身免疫性疾病患者(B组),40例非LN肾脏疾病患者(C组),30例健康对照者(D组)的血清C1qAb水平。结果①A组患者血清C1qAb水平显著高于C组患者(P<0.05),C组患者血清C1qAb水平显著高于B组(P<0.05),B组患者血清C1qAb水平显著高于D组(P<0.05)。②活动期SLE患者血清C1qAb水平显著高于稳定期SLE患者(P<0.05)。③LN患者血清C1qAb水平显著高于非LN的SLE患者(P<0.05)。结论血清C1qAb水平可作为判断SLE患者病情活动情况、并发LN与否的重要指标。

Objective To investigate the relationship of serum anti-C1 q autoantibodies （ClqAb） to disease activity and Lu- pus nephritis （LN） in Systemic lupus erythematosus （SLE）. Methods The serum C1 qAb of 60 cases of SLE （Group A） ,40 ca- ses of non-SLE patients with autoimmune diseases（ Group B） ,40 cases of non-LN patients with renal diseases（ Group C） ,30 ca- ses of healthy controls （ Group D ） was measured by Enzyme-linked immnnosorbent assay （ELISA）. Results （~The serum C1 qAb in Group A was significantly higher than that in Group C （ P 〈 O. 05 ）, which was significantly higher than that in Group B （ P 〈 0.05 ）, and the serum C lqAb in Group B was significantly higher than that in Group D （P 〈 0.05 ）. （~）The serum C1 qAh in pa- tients with active SLE was significantly higher than that in patients with stable SLE（P 〈0.05 ）. （~）The serum ClqAb in patients with LN was significantly higher than that in non-LN patients with SLE （ P 〈 0.05 ）. Conclusion The serum ClqAb provided an indicator that can be used to judge the disease activity and complication with LN in SLE.