不同孕期HIV/AIDS孕妇接受抗病毒治疗的效果评估

Effect Evaluation of HIV/AIDS Pregnant Women of Different Pregnancy Receiving Antiviral Treatment

目的探讨不同孕期的艾滋病(AIDS)/人类免疫缺陷病毒(HIV)孕妇启用高效抗逆转录病毒治疗(HAART)后母婴传播阻断效果和新生儿情况分析。方法对HIV感染发现时的孕期进行分组,分别对其进行抗病毒治疗,观测母亲围产期免疫参数、新生儿身体指证和HIV感染率。结果 61例孕妇在分娩前接受超过6周的抗病毒药物治疗,其病毒载量均比原水平降低超过10倍;分娩前7例(10.4%)孕妇检测到HIV-1 DNA,其中,2例为产前发现并用药组,3例为孕中期组,2例为孕晚期组。筛查67例婴儿发现孕晚期和产前用药组各有1例18月龄HIV阳性者。结论在孕早期/中期应用HAART预防HIV母婴传播的效果优于孕晚期,可有效阻断新生儿的HIV感染,改善新生儿结局。

Objective To explore different pregnancy AIDS （AIDS）/human immunodeficiency virus （HIV） pregnant women enable efficient antiretroviral therapy（HAART） on mother-to-child transmission blocking effect evaluation and neonatal situation analysis. Methods According to the discovery of HIV infection of pregnancy group research, the antiviral treatment, observation of other perinatal immune parameters, neonatal body index and HIV infection rate were conducted and analyzed. Results A total of 61 cases of pregnant women before childbirth accepted more than six weeks of antiviral drug therapy,the viral load were better than the original level by more than 10 times;Ante partum had 7 cases（ 10.4% ） pregnant woman can detect HIV-1 of DNA,2 cases of prenatal found and medicine group ,3 cases of pregnant medium-term group ,2 cases of late pregnancy group. Screening 67 cases of baby found late pregnancy and prenatal treatment group, each had 18 months testing HIV positive 1 case, the rest were HIV negative. Conclusion In the early/middle stages of pregnancy,the effect of HAART application to prevent HIV mother-to- child transmission was better than that of late pregnancy, which can effectively block the neonatal HIV infection, and improve neo- natal outcome.