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帕罗西汀治疗急性心肌梗死伴焦虑抑郁的疗效观察 被引量:11

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摘要 目的观察抗抑郁药帕罗西汀治疗急性心肌梗死伴有焦虑、抑郁症状患者的近期疗效。方法采用贝克抑郁调查表(Beck Depression Inventory,BDI)进行问卷调查,将问卷调查评分>10分的52例急性心肌梗死患者中随机分为A组和B组,各26例,B组除常规冠心病二级预防治疗外,还给予心理干预和口服选择性5-羟色胺再摄取抑制剂(SS-RIs)类抗抑郁药物盐酸帕罗西汀10~20 mg/d治疗;A组仅给予常规冠心病二级预防治疗。结果 B组经治疗后较A组BDI评分明显下降(P<0.05),梗死后心绞痛或再次心肌梗死的发生率显著降低(P<0.05),差异有统计学意义。但心脏性猝死率差异无统计学意义(P>0.05)。结论对合并焦虑、抑郁状态的急性心肌梗死患者进行心理干预同时联合盐酸帕罗西汀治疗,可明显改善患者的焦虑、抑郁症状,提高急性心肌梗死的疗效。
出处 《中华全科医学》 2013年第7期1078-1079,共2页 Chinese Journal of General Practice
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