摘要
目的制备法罗培南钠缓释微丸,并对其体外释药特性进行研究。方法挤出滚圆法制备载药丸芯;以乙基纤维素N-100为包衣材料,以聚维酮k30为致孔剂,流化床包衣制备法罗培南钠缓释微丸;考察包衣增重、致孔剂用量等因素对缓释微丸释放度的影响,并考察其体外释药特征及释药机制。结果所制备的微丸有明显的缓释特征,体外释放符合Higuchi释药动力学方程。结论制备的法罗培南钠缓释微丸具有较理想的体外缓释效果。
Objective To prepare Sodium Faropenem Sustained - release Pellets and investigate the drug release mechanism in vitro. Methods At first, sodium faropenem pellets were prepared by extrusion - spheronization equipment, and then coated by ethylcellulose N - 100 and povidone as porogen using the fluid - bed. Results The pellets had a re-markable sustained - release property, the drug release profile in vitro followed Higuchi kinetics. Conclusion The prepared pellets had better sustained - release characteristics in vitro.
出处
《药学研究》
CAS
2013年第5期287-288,291,共3页
Journal of Pharmaceutical Research
关键词
法罗培南钠
缓释微丸
流化床
包衣
Sodium faropenem
Sustained - release pellets
Fluld - bed
Coating
