遗传因素对高血压病人群靶器官损害发生的影响

Effect of genetic factors on target organ damage in patients with essential hypertension

目的 探讨血管紧张素Ⅱ 1型受体 (AT1R)A/C 116 6多态性、纤溶酶原激活物抑制剂 -1(PAI -1) 4G/ 5G多态性与高血压病人群肾脏损害 (RD)和脑梗死 (CI)发生的关系。方法 以高血压病人群为随机研究对象 ,采用等位基因特异性寡核苷酸探针杂交法分析AT1R基因型和PAI-1基因型。结果 (1)AT1R基因型与肾脏功能显著相关 ,AC基因型肾脏功能显著差于AA基因型 ,PAI -1基因型与肾脏功能无显著性关系 ;(2 )AT1R基因型与CI发生无显著性关系 ;CI阳性与CI阴性高血压病人群相比 ,PAI -1基因型分布有显著性差异 ,前者 4G/ 4G基因型频率显著高于后者。结论 AT1RAC基因型和PAI -14G/

Objective To investigate the influences of angiotensin Ⅱ type 1 receptor(AT 1R)A/C 1166 polymorphism and plasminogen activator inhibitor-1(PAI-1) 4G/5G polymorphism on the development of renal damage(RD) and cerebral infarction(CI) in patients with essential hypertension(EH).Methods The patients with EH were randomly enrolled in the study.AT 1R and PAI-1genotypes were analyzed by the allele specific oligonucleotide hybridization technique.Results 1.AT 1R genotypes were significantly related to renal function,with renal function in AC genotype worse than that in AA genotype.PAI-1 genotypes were not significantly associated with renal function;2.AT 1R genotypes were not significantly associated with CI.There was a significant difference in PAI-1 genotypes distribution between the patients with CI and the patients without CI,with the 4G/4G genotype frequency in the former higher compared to that in the latter.Conclusion AT 1R AC genotype and PAI-1 4G/4G genotype are risk factors for RD and CI in population with EH,respectively.