多重感染肺炎患儿临床与病原学研究

Study on the etiology and clinical manifestation in mixed infective pneumonia

目的 :探讨双重或多重感染肺炎患儿病原学与临床方面的关系。方法 :聚合酶链反应 (PCR)方法检测支原体 (MP)DNA ,酶联免疫吸附实验 (ELISA)方法检测各种病毒特异性IgM。结果 :检出双重或多重感染肺炎 32例 ,阳性率 2 8.1% ,均有MP感染 ,结合临床出现 ,双重或多重感染以婴儿为主 ,且有两个多发年龄组 :<1岁 18例 (56 .3% ) ,3岁～ 7岁 10例 (31.3% )结论 :MP与病毒是双重或多重感染肺炎的主要致病原 ;临床表现上婴幼儿主要表现为病毒性肺炎 ,学龄儿主要表现MP肺炎。

Objective:To probe into the relation between etiology and clinical manifestation in children with mixed infective pneumonia.Methods:Polymerase chain Reaction (PCR) was used to determine Mycoplasma DNA and multiple virus spectfic lgM antibodies were measured by enzyme_linked immunosorbent assay (ELISA).Result:32 cases of double mixed infective pneumonia were found, the positive rate of which was 28.1%.All the children of the 32 cases were infected by MP.The children were susceptible to double or mixed infection in two age ranges, 18 cases of which were 1 year younger (56.3%) and 10 cases of which 3 to 7 years old.Conclusion:MP and virus are the important pathogenic microorganism of double or mixed infective pneumonia. Clinical manifestations:mixed infective pneumonia looks like virus pneumonia in children younger than 3 years old,and looked lik MP pneumonia in school children