急性白血病患者血浆纤维蛋白原检测的临床意义

Clinical significance of plasma fibrinogen detection in acute leukemia patients

目的探讨急性白血病患者血浆纤维蛋白原水平的变化及其临床意义。方法采用Sysmex CA-1500全自动血凝仪对急性白血病患者治疗前后以及健康人血浆纤维蛋白原水平进行检测并比较差异。结果急性白血病初治患者纤维蛋白原水平明显增高,与对照组比较,差异有统计学意义(P<0.01),经治疗后达缓解者纤维蛋白原水平明显下降,与治疗前比较差异有统计学意义(P<0.01),而治疗后未缓解者与治疗前比较差异无统计学意义(P>0.05)。结论血浆纤维蛋白原在急性白血病的诊断及疗效判断中有一定的临床意义。

Objective To investigate the change of plasma fibrinogen levels and its clinical value in the patients with acute leukemia. Methods Sysmex CA-1500 full-automatic bkxxl coagulation analyzer was used to detect and compare the difference of the plasma fibrinogen levels in acute leukemia patients before and after treatment, and the healthy people. Results The plasma fibrinogen levels were increased in acute leukemia patients remarkably, significantly higher than those in the normal control group （P〈 0.01 ）. After treatment, the plasma fibrinogen levels in remission phases were obviously reduced, significantly different from those before treatment （ P 〈 0.01 ）. However, the plasma fibrinogen levels in non-remission phases had no significant difference from those before treatment（ P 〉0.05 ）. Conclusions The plasma fibrinogen level has certain clinical significance in the diagnosis and evaluation of therapy in acute leukemia patients.