摘要
脱氧核糖核酸酶Ⅰ是一种核酸内切酶,参与细胞凋亡过程和坏死细胞染色质的降解。在一过性心肌缺血、急性冠状动脉综合征中早期(发病3 h内),可以检测到血清脱氧核糖核酸酶Ⅰ的升高,差异具有统计学意义(P<0.05)。它不仅是急性冠状动脉综合征早期的诊断标志物,还参与了心室重塑的病理生理过程。
Deoxyribonuclease I is a kind of endonuclease which participated in the process of cell apoptosis and the degradation of chromatin of necrotic cells. There is a significantly increased deoxyribonuclease I in serum in the transient myocardial ischemia and earlier a- cute coronary syndrome （in 3 hours）, compared with the control groups with a significant difference （P 〈 0.05）. It＇s not only the marker of the earlier acute coronary syndrome, but also participate in pathophysiological process of the ventricular remodeling.
出处
《心血管病学进展》
CAS
2013年第3期430-433,共4页
Advances in Cardiovascular Diseases
关键词
脱氧核糖核酸酶I
心肌缺血
心肌梗死
deoxyribonuclease I
myocardial ischemia
myocardial infarction
