急性白血病凋亡因子Fas配基的表达研究

The expression of apoptotic factor Fas ligand in acute leukemia

目的：研究Fas配基在急性白血病的表达与意义。方法：用免疫组化SP法检测临床55例急性白血病Fas配基的表达。结果：16/55的急性白血病患者出现白血病细胞Fas配基阳性；阳性病例均为急性髓性白血病(16/39)；Fas配基阳性细胞占白血病细胞总数的(59.6±29.8)％。结论：Fas配基在部分急性髓性白血病中高表达，Fas/Fas配基途径可能参与这部分急性髓性白血病的免疫逃避。

Objective： To investigate the expression of Fas ligand in acute leukemia and its significance. Method： The Fas ligand expression in 55 cases of acute leukemia was examined by using SP method of immunohistochemical staining. Results： Sixteen cases of acute leukemia were Fas ligand positive which were all acute myeloid leukemia(AML). There were (59.6± 29.8)％ of blast cells stained by antibody of Fas ligand in all of the leukemic cells. Conclusions： The Fas ligand appears overexpression in some AML. The pathway of Fas/Fas Ligand may involve in the mechanism of immune escape in AML.