聚谷氨酸酯的碱解脱酯研究

Study on Alkaline Hydrolysis of Polyglutamate for De esterification

报道了不同比例的谷氨酸甲酯和谷氨酸苄酯共聚物在碱的作用下 ,水解生成谷氨酸甲酯 -谷氨酸苄酯 -谷氨酸共聚物的方法。研究表明 :谷氨酸甲酯均聚物碱解较快 ,而谷氨酸苄酯均聚物与稀碱在室温下反应很小。共聚物中谷氨酸甲酯含量越大 ,碱浓度越大 ,碱解时间越长 ,薄膜厚度越小 ,碱解的程度也就越大 ,碱解产物中谷氨酸链节的含量也越大。

This paper reports the alkaline hydrolysis of poly(methyl glutamate), poly (benzyl glutamate) and copoly(methyl glutamate benzyl glutamate glutamic acid)for de esterification. The results showed that in this process of alkaline hydrolysis the demethylation of poly(methyl glutamate)was faster, but debenzylation of poly(benzyl glutamate) was hardly processed. An increase in the methyl glutamate content of starting copolymers, in the alkaline concentration and the time of alkaline hydrolysis, and a decrease in the film thickness, would lead to a raise in the degree of alkaline hydrolysis, that is, an increase of the glutamic acid segment content in product of alkaline hydrolysis.