抗肿瘤酶制剂L-天冬酰胺酶治疗白血病的研究进展

Progress in Researches on Anti-tumor Agent L-asparaginase for Treatment of Leukemia

L-天冬酰胺酶具有显著的抗肿瘤作用。为了最大限度地发挥酶疗法的优势 ,可以对天然酶进行化学改性、包埋或固定化。尤其值得重视的是固定化酶体外循环净化血浆技术 ,该研究对人类攻克白血病提出了一个新的思路与方法 。

L asparaginase is a very effective anti tumor agent. To take the most advantage of enzyme treatment method, the natural L asparaginase could be chemically modified, entrapped or immobilized into/onto other carriers. The extracorporeal shunt system with immobilized enzyme reactor deserves to receive special attention. It provides an entirely new idea for leukemia treatment and is proved to be very prospective in the future leukemia cure.