摘要
提出了一种新的长春西汀合成方法,并对反应条件进行了优化。长春胺(2)经氯化亚砜脱水得到阿扑长春胺(3),再经氢氧化钠水解得到阿扑长春胺酸(4),最后在经氯化亚砜和乙醇酯化得到长春西汀(1)。经此方法,长春西汀合成总收率达82.8%,纯度达99.5%。通过1H-NMR,13C-NMR,EI-MS对产物结构进行了确证。
A novel synthesis method of vinpocetine was proposed. The influence factors of each step were investigated and the reaction conditions were optimized, apovincamine （3） was produced from vincamine （2） by dehydration under sulfoxide chloride. The raw material apovincamine acid （4） was produced from apovincamine by sodium hydroxide, vinpocetine （1） was obtained from apovincamine acid by esterification. The yield and purity of vinpocetine were 82.8% and 99.5%, respectively. The structure of the product was identified by JH-NMR, ^13C-NMR and El-MS.
出处
《化工技术与开发》
CAS
2013年第3期9-11,共3页
Technology & Development of Chemical Industry
关键词
长春胺
长春西汀
合成
氯化亚砜
vincamine
vinpocetine
synthesis
sulfoxide chloride
