摘要
目的探讨分析胃癌组织中Bmi-1蛋白表达与胃癌患者病理因素及预后的关系。方法回顾性分析该院2008年1—12月间收治60例行胃癌切除术的胃癌患者的临床资料,随访3年且资料完整。对所有患者的手术标本经石蜡切片采用免疫化学组织法染色,对Bmi-1蛋白的具体表达情况进行检测,分析Bmi-1蛋白表达与胃癌患者病理因素及预后的关系。结果 Bmi-1蛋白表达的阳性率为68.33﹪(41/60)。Bmi-1蛋白表达与病灶大小、癌症分期、侵润深度、淋巴结的转移呈相关性。Bmi-1蛋白表达呈阳性的患者与Bmi-1蛋白表达呈阴性的患者的死亡率、平均生存期比较,差异有统计学意义(P<0.05)。结论 Bmi-1蛋白表达与胃癌的复发、转移呈相关性,可以作为判断胃癌患者预后的重要指标。
Objective To investigate the analysis of Bmi-1 protein expression in gastric cancer patients with pathological factors and prognosis of gastric carcinoma. Methods A retrospective analysis of the clinical data of patients with gastric cancer in our hospital were treated between January 2008 December 2008 60 routine gastric resection, the 3-year follow-up and data integrity. Immunochemical staining of tissue paraffin sections of surgical specimens in all patients after detection of Bmi-1 protein expression analysis of the relationship between Bmi-1 protein expression in gastric cancer patients with pathological factors and prognosis. Results Bmi-1 protein expression positive rate of 68.33%（41/60）. Bmi-1 protein expression and tumor size, cancer stage, depth of invasion, lymph node metastasis correlation. Bmi-1 protein expression in patients with positive expression of Bmi-1-negative patients with mortality, average survival time of more significant difference, P 0.05, statistically significant. Conclusion Bmi-1 protein expression in gastric cancer recurrence, metastasis, can be used as an important indicator to judge the prognosis of patients with gastric cancer.
出处
《中外医疗》
2013年第10期31-31,33,共2页
China & Foreign Medical Treatment
关键词
Bmi-1蛋白表达
胃癌
病理因素
预后
Bmi-1 protein expression
Gastric cancer
Pathological factors
Prognosis
