中西医结合治疗难治性消化性溃疡56例临床观察

Integrative Medicine Clinical Observation on Treatment of 56 Cases of Refractory Peptic Ulcer

目的探讨中西医结合治疗难治性消化性溃疡的疗效。方法 112例患者随机分为治疗组、对照组各56例。治疗组给予自拟四君子愈疡汤配合左氧氟沙星+奥美拉唑+呋喃唑酮(每次0.2g+20mg+200mg,2次/d,口服);对照组给予左氧氟沙星+奥美拉唑+呋喃唑酮(每次0.2g+20mg+200mg,2次/d,口服);两组均1周为1个疗程。2个疗程结束后,对两组的疗效、幽门螺旋杆菌(Hp)根除率进行对比分析。结果治疗组总有效率为94.46%,对照组为78.57%,治疗组和对照组的Hp根除率分别为88.46%,70.0%。两组的总有效率和Hp根除率比较,差异有统计学意义(P<0.05)。结论采用中西医结合治疗难治性消化性溃疡,其疗效确切,效果显著,对于难治性消化性溃疡患者具有十分重要的临床治疗意义。

Objective To investigate the clinical efficacy of integrative medicine on treatment of refractory peptic ulcer. Methods A total of 200 patients were randomly divided into study group and control group with 56 cases in each. Treatment group were administrated Sijunzi Yuyang decoction combined with Levofloxacin ＋ omeprazole ＋ Furazolidone（each 0.2 g＋20 mg＋200 mg, twice a day, po） for 2 weeks; Control group were treated with Levofloxacin ＋ omeprazole ＋ Furazolidone（each 0.2 g＋20 mg＋200 mg, twice a day, po） for 2 weeks, and then clinical efficacy and Hp eradication rate of the two groups were compared and analyzed. Results The cure rate of treatment group was 94.46%, while that of the control group was 78.57%, the Hp eradication rate between the treatment group and control group were 88.46% and 70.0%. There were statistically significant between two groups（P〈0.05）. Conclusion The clinical efficacy of integrative medicine on treatment of refractory peptic ulcer is accurate and obvious, and it has great clinical significance for the patients with refractory peptic ulcer.