丹参有效成分抗肝纤维化作用机制的研究进展

Research progress in anti-hepatic fibrosis mechanism of Salvia Miltiorrhiza

肝纤维化是多种病因引起肝损害后经一系列连锁反应最终可进展为肝硬化的病理过程。通过大量研究现已证实肝纤维化可被逆转,而中药以其多途径的治疗特点在抗肝纤维化治疗上具有极大优势。丹参是临床常用的抗肝纤维化的中药,具有很好的疗效,主要成分有丹参酮、丹酚酸和丹参单体IH764-3。已有大量研究阐明了丹参抗肝纤维化的分子机制,其对肝纤维化形成的各个环节均有影响,如抗炎症反应、抑制炎症因子释放、抗氧自由基损伤、抑制星状细胞活化、抑制胶原过度沉积、改善微循环障碍等。本文即对丹参有效成分在肝纤维化治疗中的多种作用及机制做一综述。

Hepatic fibrosis is a pathological change which is caused by a variety of stimuli and after a series of chain reaction will progression to cirrhosis of the liver. A large number of studies have con- firmed that the Liver fibrosis is reversible. Traditional chinese medicine （TCM） has the advantage in the treatment of liver fibrosis with the aid of muhiple targets. Salvia miltiorrhiza is a TCM in the clinic which is commonly used to treatment of liver fibrosis and has the very good curative effect. The main active constitu- ents of Salvia miltiorrhiza including tanshinone , salvianolic acid and Salvia miltiorrhiza monomer IH764-3, a great deal of research has been performed to understand the molecular mechanisms responsible for the an- ti-hepatic fibrosis effect of Salvia miltiorrhiza, it have the effect for each link of the process that lead to he- patic fibrosis, such as anti inflammatory response, depressing release of inflammatory factors, resisting peroxidative damage of free radical, depressing the activation of HBC, depressing excess deposition of collagen, improve the microeirculation and so on. This paper is a review about salvia miltiorrhiza resistance mechanism of liver fibrosis.