硅溶胶/Nano-Au固定联吡啶钌电化学发光行为的研究

Electrochemiluminescence based on a silica sol/Nano-Au/Ru(bpy)_3^(2+) modified Au electrode

研究了舒必利在硅溶胶/纳米金/联吡啶钌修饰的金电极上的电化学发光行为,建立了电化学发光法检测舒必利的新方法。在最佳实验条件下,舒必利浓度在1.0×10-6～1.0×10-4mol/L范围内与发光强度呈良好的线性关系(r2=0.9954),检出限(S/N=3)为3.4×10-9mol/L。连续平行测定1.0×10-5mol/L的舒必利溶液8次,发光强度的相对标准偏差(RSDs)为1.5%。该电极用于样品测定,回收率为97.6%～102.1%。结果表明,纳米金表现出较好的电分析活性,对联吡啶钌具有较好的电催化作用,并可应用于舒必利药物的测定。

The electrochemical and electrochemiluminescence characteristics of sulpiride at a silica sol/Nano-Au/ Ru（bpy）3 2＋ modified Au electrode were investigated. An electrochemiluminescence method for the determination of sulpiride was established. Under the optimum conditions,the calibration curve showed a good linearity over sulpiride concentration in the range of 1.0×10^-6-1.0×10^-4mol/L （r2 =0. 9954）, and the detection limit（s/N=3）为3.4×10^-9mol/L. The RSD for 8 -time determinations of 1.0×10^-5mol/L sulpiride was 1.5%. The Silica sol/ Nano-Au/Ru（bpy） 32＋ modified Au electrode can be applied to the determination of sulpiride in tablet samples with satisfactory results. The recoveries were between 97. 6% and 102. 1%. The results clearly showed that Au nanotubes possessed excellent electrocatalytic activity, also could accelerate electron transfer rate between the redox-active Ru（bpy）31＋ and the electrode. The results showed that the proposed method was sensitive for the determination of sulpiride.