东方田鼠抗日本血吸虫病现象的观察

THE OBSERVATION FOR THE PHENOMENON OF MICROTUS FORTIS AGANISTING SCHISITOSOMA JAPONICUM

本试验分别应用 1 0 0 0条、2 0 0条和 40条日本血吸虫尾蚴人工攻击感染东方田鼠、金黄地鼠和 Balb/c小鼠 ,在攻击后第 1、2、3、4、7、9、1 2、1 5、1 6、1 8、1 9、2 1、2 2、2 4、42天时分别将其剖杀 ,集虫 ,观察。结果观察到血吸虫在东方田鼠体内不能发育成熟 ,在攻击后 1 9天时虫体已全部死亡。而金黄地鼠和 Balb/c小鼠的虫体回收率分别为 65%和 60 .6%。在虫体移行时 ,东方田鼠肺组织和肝组织也出现炎症反应 ,但病变要比金黄地鼠和 Balb/c小鼠轻 ,并很快地修复 ,恢复正常。试验表明 。

Microtus fortis, Golden hamster,Balb/c mouse was infected by 1000,200 and 40 Schisitosoma japonicum lercariae separately in laboratory.On the day of the 1 st ,2 nd ,3 rd ,4 th ,5 th ,7 th ,9 th ,12 th ,15 th ,16 th ,18 th ,19 th ,21 st ,22 nd ,24 th and 42 nd after infected, the three kinds of each mice were dissected. Worms were collected,and checked under microscope.It was found that Schisitosoma japonicum can not grow up in Microtus fortis, and all of the worms are disappearance on 19 th day.However,the recovery rates of worms collected from Gold hamster,Balb/c mouse was 65% and 60.6% separately.The inflammation reactions were observed in the lung and liver tissues while the Microtus fortis was infected, but the pathological changes were not so serious as that seen in Golden hamster and Balb/c mice,and recovered normal very soon.The experiment testified that the Microtus fortis did resist on Schisitosoma japonicum.