AIDS合并新生隐球菌感染的检测及药敏分析

Detection and Susceptibility Testing of AIDS with Cryptococcus Neoformans Infection

目的了解临床新生隐球菌的分离及该菌对抗真菌药物的耐药情况,提高对获得性免疫缺陷综合征(AIDS)合并隐球菌感染的认识。方法对2010年5月至2012年10月我院临床分离的新生隐球菌进行统计,并分析其耐药变化。结果 23株新生隐球菌中,15株于脑脊液中分离出,占65.2%,8株分离于血液,占34.8%,脑脊液中分离出的新生隐球菌占多数,。两性霉素B、5-氟胞嘧啶、伏立康唑对新生隐球菌敏感率均为100%,氟康唑敏感率为56.5%,伊曲康唑对新生隐球菌敏感率最低为17.4%。脑脊液中分离出的新生隐球菌占多数。结论随着AIDS患者数的增多,AIDS合并隐球菌感染的发生率呈上升趋势,应加强临床合理使用抗菌药物的管理,预防和减少多药耐药菌的产生。

Objective Understanding of the clinical Cryptococcus neoformans separation and the bacteria antifungal resistance,to raise awareness of the Acquired Immune Deficiency Syndrome（AIDS） merger cryptococcal infection.Methods Cryptococcus neoformans clinical isolates in our hospital from May 2010 to October 2012,the statistics and analysis of resistance changes.Results 23 Cryptococcus neoformans,15 in the cerebrospinal fluid of isolated,accounting for 65.2% and 8 isolated in the blood,and 34.8%,Cryptococcus neoformans isolated in the cerebrospinal fluid of a majority.Amphotericin B,5-flucytosine,voriconazole on Cryptococcus neoformans sensitive rate are 100%,fluconazole sensitivity was 56.5%,itraconazole Cryptococcus neoformans sensitive rate as low as 17.4%.Cryptococcus neoformans isolated in the cerebrospinal fluid of a majority.Conclusion With the increase in the number of AIDS patients and AIDS combined incidence of cryptococcal infection is rising,we should strengthen the management of clinical rational use of antibiotics to prevent and reduce the production of multi-drug resistant bacteria.