别嘌呤醇致Stevens-Johnson综合征及中毒性表皮坏死松解症的发病机制和治疗

Allopurinol Induced Pathogenesis and Treatment of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis

别嘌呤醇是次黄嘌呤的同分异构体,在体内可抑制黄嘌呤氧化酶而抑制体内尿酸合成,是目前临床广泛使用的唯一一个抑制尿酸合成的抗痛风药,其可诱发Stevens-Johnson综合征和中毒性表皮坏死松解症。SJS/TEN虽较为少见,却是危及生命的严重皮肤不良反应。因此对于SJS/TEN发病机制的认识,可以有效预防SJS/TEN的发生,而正确治疗措施的采取将减少并发症的发生,降低病死率。本文就SJS/TEN的发病机制及治疗进行综述。

Allopurinol was an isomer of hypoxanthine,and could inhibit uric acid synthesis by inhibiting xanthinoxidase in vivo.Allopurinol was the only antipodagric which inhibit uric acid synthesis,it currently widely used in clinical and may be induced Stevens-Johnsonsyndrome（SJS） and toxic epidermal necrolysis（TEN）.SJS/TEN were rare but life-threatening severe cutaneous adverse reactions（SCARs）.So understanding of the pathogenesis for SJS/TEN could be effective in preventing the occurrence of SJS/TEN,and adopt correct therapeutic measure would reduce the incidence of complications and reduce mortality.In this review we summarized the pathogenesis and treatment of SJS/TEN.