核因子kappa B与卵巢上皮癌血管生成及复发的关系研究

the Relationship with Angiogenesis and Relapse of Nuclear Factor-kappa B in Ovarian Epithelial Carcinoma

目的研究核因子kappa B(nuclear factor-kappa B,NF-κB)与卵巢上皮癌(ovarian epithelial carcinoma,OEC)血管生成及复发的关系。方法应用免疫组化方法检测36例OEC,15例卵巢良性肿瘤和15例正常卵巢组织微血管密度(Microvessel density,MVD),碱性成纤维生长因子(basic fibroblast growth factor,bFGF)和NF-κB的表达。同时研究NF-κB和bFGF,MVD关系及OEC患者1、3、5年复发率。结果 NF-κB在OEC中的阳性表达率显著高于良性肿瘤和正常卵巢组织。在NF-κB阳性表达组,MVD和1、3、5年复发率显著高于NF-κB阴性组。NF-κB表达与MVD和bFGF表达正相关。结论 NF-κB可能通过上调bFGF的表达促进血管生成引起OEC的转移和复发。

Objective To investigate the relationship with angiogenesis and relapse of nuclear factor-kappa B（NF-κB）in ovarian epithelial carcinoma（OEC）.Methods Microvessel density（MVD）,expression of basic fibroblast growth factor（bFGF） and NF-κB were investigated in 36 cases of OEC,15 cases of ovarian benign tumor and 15 cases of normal ovarian specimens by immunohistochemical staining.The relationship between the NF-κB and bFGF,MVD and relapse rate of I,3 and 5 years of OEC patients were also studied.Results Positive expression rate of NF-κB in OEC was significantly higher than that of benign tumor and normal ovarian tissue.In NF-κB positive expression group,MVD and relapse rate of 1,3 and 5 years were significantly higher than those in NF-κB negative group.There were positive relationship between the expression of NF-κB and MVD.Conclusion NF-κB might promote angiogenesis through up-regulating bFGF expression and cause cancer metastasis and relapse in OEC.