早期复极312例临床分析

General Situation and ECG(Electrocardiogram) Characteristics of Early Repolarization Pattern

目的探讨早期复极改变患者的一般情况以及心电图特征。方法选择2010年1月28日-2012年5月2日南京医科大学第一附属医院心电图室诊断为早期复极改变312例患者为研究对象,体检中心325例正常人群为对照组,对其一般情况以及心电图特征进行对照分析。结果早期复极改变的发生率为0.22%(312/145 020),男女比例为303∶9(33.7∶1),平均年龄(39.66±14.25)岁,与正常人群相比,体重[(65.66±10.20)kg VS(71.43±9.49)kg,P<0.05]、BMI(22.24±3.00 VS 24.50±2.76,P<0.05)、心率明显降低[(65.68±8.62)次/min VS(71.30±9.46)次/min,P<0.05],P波时限[(101.07±14.78)ms VS(106.80±19.90)ms,P<0.05]、QTC[(400.18±31.00)ms VS(408.80±21.65)ms,P<0.05]明显缩短,QRS波时限[(107.91±24.09)ms VS(104.54±9.20)ms,P<0.05]较长,P-R间期无明显差异。结论早期复极改变患者的临床特征和心电图特征,可为早期复极的诊断提供参考,但不能作为其独立的危险因素。具体机制仍需更多的临床合作和更多的基础研究来探讨。

Objective To investigate the general situation and ECG（Electrocardiogram） characteristics of early repolarization pattem（ERP）. Methods People who was diagnosed with ERP in the First Affilliated Hospital of Nanjing Medical University （n = 312） from January 28,2010 to 2012 on May 02,2010 and healthy people from Examination Center of the same hospital were inclued. The general situation and ECG characteristics of the two teams were compared. Results ERP was present in 312 of 145 020（0.22% ）. The proportion of male and female was 33.7： 1 and the average age was（39.66 ± 14.25） years old. Lower weight （65.66 ± 10.20 VS 71.43 ± 9.49 kg P 〈 0.05 ）, lower BMI （22.24 ± 3.00 VS 24.50 ± 2.76 P 〈 0.05 ）, lower heart rate （65.68 ± 8.62 VS 71.30 ± 9.46 次min P 〈 0.05 ）, shorter p wave duration （ 101.07 ± 14.78 VS 106.80 ± 19.90 ms＇ P 〈 0.05 ）, longer QRS duration （ 107.91 ± 24.09 VS 104.54 ± 9.20 ms P 〈 0.05 ） and shorter QTC duration （400.18 ± 31.00 VS 408.80 ± 21.65 ms P 〈 0.05） were associated with the presence of early repolarization. Conclusion ERP had strong association with clinical factors and ECG characteristics,which can assist in diagnosis of ERP, but can not be treated as independent risk fac- tors. More clinical cooperation and more basic research were needed to investigate the underline mechanisms.