摘要
目的:利用Meta分析的方法,比较黄体酮经阴道给药及肌肉注射在辅助生殖技术中黄体支持治疗的临床疗效。方法:选取发表于1990年1月至2011年12月的文献,对比分析所有比较黄体酮经阴道给药及肌肉注射治疗效果的临床随机对照试验,并应用Meta分析方法评价上述两种给药方式的临床结局。结果:共纳入13个研究2 741例患者。Meta分析的结果显示:黄体酮阴道给药组与肌肉注射组在黄体支持治疗的临床妊娠率[OR=1.09,95%CI(0.77,1.54)]、继续妊娠率[OR=1.11,95%CI(0.71,1.73)]以及流产率[OR=0.77,95%CI(0.53,1.13)]是无统计学差异的。结论:辅助生殖技术中行黄体支持治疗的两种不同给药方法:黄体酮阴道及肌肉注射给药在提高临床妊娠结局上的疗效是相似的。
Objective: To compare the clinical efficiency of intravaginal and intramuscular progesterone of luteal phase support therapy in assisted reproductive technology by meta analysis.Methods: Clinical trials were retrieved from January 1990 to December 2011 comparing intravaginal progesterone and intramuscular progesterone in luteal phase support treatment.Meta-analysis was adopted to evaluated the clinical outcomes.Results: Thirteen studies involving 2 741 patients met the inclusion criteria.The results of metaanalysis showed there was no statistical difference between intravaginal and intramuscular progesterone on the rate of clinical pregnancy(OR = 1.09,95% CI[0.77,1.54]),ongoing pregnancy(OR = 1.11,95% CI [0.71,1.73]) or miscarriage(OR = 0.77,95% CI [0.53,1.13]) in the luteal phase support.Conclusion: The administration of vaginal progesterone is comparable to administration of intramuscular progesterone for luteal phase support in assisted reproductive technology.
出处
《武汉大学学报(医学版)》
CAS
北大核心
2013年第3期467-472,共6页
Medical Journal of Wuhan University