叶酸和维生素B对缺血性脑卒中患者血清中高同型半胱氨酸水平的影响

Effect of folic acid and vitamin B on ischemic stroke patients with hyperhomocysteinemia

目的探讨叶酸和维生素B对缺血性脑卒中血清高同型半胱氨酸水平的影响。方法 120例高同型半胱氨酸血症的急性缺血性脑卒中患者随机分为干预组和非干预组(均n=60)。两组均给予常规治疗,干预组加用叶酸5 mg、甲钴胺500μg、维生素B620 mg,每日3次,口服4周,随访6个月。比较治疗前后患者血清同型半胱氨酸(Hcy)水平,评价首次发病后6个月内脑卒中事件复发情况。结果干预前,两组患者血清Hcy水平无显著差异(P>0.05),予以叶酸、甲钴胺和维生素B6干预后,干预组血清Hcy水平明显下降,与非干预组相比差异显著(P<0.05)。结论补充叶酸、甲钴胺和维生素B6有助于降低血浆Hcy水平,减少缺血性脑卒中患者复发。

AIM To discuss the effect of folic acid and vitamin B on the ischemic patient with hyperhomocysteinemia. METHODS One hundred and twenty patients with acute ischemic stroke and hyperhomocysteinemia were randomly divided into intervention group and non-intervention group （n = 60） . In addition to the conventional treatment, the intervention group was added with folic acid 5 mg, mecobalamin 500 μg and vitamin B6 20 rag, rid, orally for 4 weeks and followed up for 6 months. The serum homocysteine level was compared before intervention with after the treatment. The recurrence of stroke was evaluated within 6 months. RESULTS Before the intervention, there was no significant difference of homocysteine level between the intervention group and the non- intervention group （P 〉 0.05） . While after the intervention, the homocysteine level in the intervention group have declined obviously, and it has significant difference compared with the non-intervention group （P 〈 0.05） . CONCLUSION Given folic acid, mecobalamin and vitamin B6can help to reduce the serum homocysteine level and reduce the recurrence of acute ischemic stroke.