G3BP1和G3BP2蛋白在大肠癌组织中的表达及临床意义

Expression of G3BP1 and G3BP2 proteins in colorectal cancer and their clinical significances

目的观察大肠癌组织中GTP酶激活蛋白SH3功能区结合蛋白(G3BP)1和G3BP2的表达变化,并探讨其意义。方法选择大肠癌组织119例(大肠癌组)、正常组织15例(正常组),采用免疫组织化学方法检测两组G3BP1蛋白和G3BP2蛋白的表达情况。结果大肠癌组和正常组G3BP1的阳性率分别为87.39%、60.00%,G3BP2阳性率分别为95.80%、66.67%,两组比较差异有统计学意义(P均<0.05);G3BP1和G3BP2的表达均与大肠癌组织学类型相关(P均<0.05);大肠癌组织中G3BP1和G3BP2表达呈正相关(rs=0.425,P=0.000)。结论大肠癌组织中G3BP1和G3BP2呈高表达,两指标异常表达可能在大肠癌的发生和发展中起重要作用。

Objective To observe the expression and significances of Ras-GTPase-activating protein SH3 domain binding protein （G3BP）1 and G3BP2 in colorectal cancer. Methods The expression of G3BP1 and G3BP2 proteins both in 119 cases of eolorectal cancer （cancer group） and 15 cases of normal tissues （control group）were detected by immunohistochemistry. Results The positive rates of G3BP1 in cancer group and control group were 87.39% and 60.00% respectively, the positive rates of G3BP2 were 95.80% and 66.67% respectively, and there were significantly different between two groups （P 〈 0.05）. Both the degree of G3BP1 and G3BP2 expression were correlated with tumor histological type （P 〈 0.05 ）. Spearman relative analysis showed that the degree of G3BP1 expression in colorectal canc- er was correlated positively with the degree of G3 BP2 expression （ r3= 0. 425, P = 0. 000）. Conclusion The expression of G3BP1 and G3BP2 proteins in colorectal cancer were high, and their abnormal expression may play important roles in the development and progress of colorectal cancer.