颅咽管瘤组织炎性反应与临床病理和肿瘤预后相关性分析

Relationship between inflammation and clinicopathological indicators and clinical outcomes in craniopharyngioma

目的探讨颅咽管瘤不同炎性反应等级与临床病理、肿瘤预后的相关性。方法根据临近肿瘤正常组织交界处的炎性反应细胞数量对颅咽管瘤进行炎性反应评估，结合临床资料，对49例经手术治疗的颅咽管瘤病例进行回顾性分析并探讨其与临床病理和肿瘤预后的相关性。结果颅咽管瘤组织炎性反应与肿瘤病理类型（χ2=6．603，P=0．037）、全切率（χ2=8．188，P=0．017）、钙化（γ=0．326，P=0．022）、术后患者下丘脑功能评分（γ=0．376，P=0．008）和手术难易度（γ=0．515，P〈0．001）相关。结论颅咽管瘤起源、生长方式及组织炎性反应程度可能是决定颅咽管瘤预后的重要因素。

Objective To study the relationship with inflammatory levels and indicators and the clinical outcomes in craniopharyngioma. Methods Evaluating the inflammatory levels of craniopharyngioma on the basis of the number of inflammatory cells at the interface of tumor and normal tissues. The relationship between grades of inflammation and clinieopathological indicators and clinical outcomes were analyzed in 49 cases of craniopharyngomas. Results The inflammation of craniopharyngioma was associated with the pathological classification （ χ2 = 6. 603, P = 0. 037）, the rate of total resection （ χ2 = 8. 188, P = 0. 017 ）, calcification （ γ = 0. 326, P = 0. 022） , postoperative hypothalamic status scale （γ= 0. 376, P = 0. 008 ）, and surgical difficulty （ γ = 0. 515, P 〈 0. 001 ）. Conclusions The origin, growth patterns, and inflammatory levels of eraniopharyngioma could be important factors that determine the prognosis of craniopharyngiomas.