期刊文献+

肝纤维化患者血清PDGF、CTGF的研究与应用

下载PDF
导出
摘要 肝纤维化是肝硬化的中间必经阶段,早期诊断、治疗肝纤维化可逆转肝硬化的发生,从而破坏"慢性肝病-肝纤维化-肝硬化-肝癌"这条"死亡链"。现就血清血小板衍生生长因子(PDGF)、结缔组织生长因子(CTGF)两因子对肝纤维化的影响以及诊断治疗方面的作用作一综述。
作者 丁圣 刘绪舜
出处 《肝胆胰外科杂志》 CAS 2013年第3期261-262,F0003,共3页 Journal of Hepatopancreatobiliary Surgery
  • 相关文献

参考文献17

二级参考文献52

  • 1Qing He Nie Yong Qian Cheng Yu Mei Xie Yong Xing Zhou Yi Zhan Cao The Center of Infectious Disease Diagnosis and Treatment of PLA,Tangdu Hospital,Forth Military Medical University,Xi’an 710038,Shaanxi Province,ChinaDr,Qing He Nie graduated from Qinghai Medical College as a doctor in 1983,got master degree at Beijing 302 Army Hospital in 1993,got doctor degree at the Third Military Medical University in 1998,engaged in postdoctoral research at the Fourth Military Medical University from 1998 to 2000,now an associate professor,specialized in clinical and experimental research of infectious diseases,had more than 90 papers published,coauthor of ten books,first author of one book..Inhibiting effect of antisense oligonucleotides phosphorthioate on gene expression of TIMP-1 in rat liver fibrosis[J].World Journal of Gastroenterology,2001,7(3):363-369. 被引量:73
  • 2罗海峰,吴志勇,邱江锋,陈炜,张志奇,孟方斌.特异性siRNA抑制肝星状细胞Smad2表达[J].外科理论与实践,2004,9(4):295-297. 被引量:9
  • 3MiaoChen,Guang-JiWang,YongDiao,Rui-AnXu,Hai-TangXie,Xin-YanLi,Jian-GuoSun.Adeno-associated virus mediated interferon-gamma inhibits the progression of hepatic fibrosis in vitro and in vivo[J].World Journal of Gastroenterology,2005,11(26):4045-4051. 被引量:25
  • 4周朝晖,蔡瑜,沈锡中,朱腾方,王吉耀.甘草酸对CCl_4肝纤维化大鼠肝组织smad7免疫组化表达的影响[J].中国临床医学,2006,13(1):67-69. 被引量:16
  • 5Pilling D,Fan T,Huang D,et al.Identification of markers that distinguish monocyte-derived fibrocytes from monocytes,macrophages,and fibroblasts[J].PLoS One,2009,4(10):e7475.
  • 6Yang Y,Yang S,Chen M,et al.Compound Astragalus and Salvia miltiorrhiza extract exerts anti-fibrosis by mediating TGF-beta/Smad signaling in myofibroblasts[J].Ethnopharmacol,2008,118(2):264-70.
  • 7Borkham-Kamphorst E,Herrmann J,Stoll D,et al.Dominant-negative soluble PDGF-beta receptor inhibits hepatic stellate cell activation and attenuates liver fibrosis[J].Lab Invest,2004,84(6):766-77.
  • 8Neil J R,Johnson K M,Nemenoff R A,et al.Cox-2 inactivates Smad signaling and enhances EMT stimulated by TGF-beta through a PGE2-dependent mechanisms[J].Carcinogenesis,2008,29(11):2227-35.
  • 9Peinado H,Quintanilla M,Cano A.Transforming growth factor beta-1 induces snail transcription factor in epithelial cell lines:mechanisms for epithelial mesenchymal transitions[J].Biol Chem,2003,278(23):21113-23.
  • 10Radisky D C,Kenny P A,Bissell M J.Fibrosis and cancer:do myofibroblasts come also from epithelial cells via EMT[J] ? Cell Biochem,2007,101(4):830-9.

共引文献51

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部