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抗原特异性TCR基因转导T淋巴细胞治疗的研究进展

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摘要 过继性细胞免疫治疗是一种有广阔应用前景的治疗肿瘤的方法。传统的方法是将自然产生的特异性肿瘤杀伤细胞(CLT)在体外扩增后回输入患者体内[1]。美国国立癌症研究所进行的临床研究表明,在转移性黑色素瘤患者身上联合使用特异性肿瘤杀伤细胞(CLT)、淋巴细胞删除性化疗和IL-2能产生50%。70%反应率。
作者 罗轶群 马骊
出处 《中国免疫学杂志》 CAS CSCD 北大核心 2013年第5期548-552,共5页 Chinese Journal of Immunology
基金 国家自然科学基金(81171539 30972680) 广东省自然科学基金重点项目(S2011020003154) 高等学校博士学科点专项科研基金(20114433110002)
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