降钙素原、C反应蛋白联合检测在新生儿感染性疾病诊断中的应用

Clinical application of combined detection of procalcitonin and C-reactive protein in the diagnosis of neonatal infectious disease

目的:研究降钙素原(PCT)、C反应蛋白(CRP)联合检测在新生儿感染性疾病的早期诊断中的临床应用价值。方法:对67例重症感染新生儿(重症感染组),58例局部感染新生儿(局部感染组),32例非感染性疾病新生儿(非感染组)及46例正常新生儿(对照组)进行PCT、CRP检测,观察各组检测结果的差异,并研究重症感染组治疗前后PCT、CRP及中性粒细胞(NEUT)的差异及相关性。结果:PCT血清浓度各组间比较均有统计学差异(P<0.05),CRP血清浓度重症感染组与其他各组比较均有统计学差异(P<0.05),局部感染组与非感染组无统计学差异(P>0.05),与正常对照组比较有统计学差异;重症感染组PCT、CRP阳性率与其他各组比较均有统计学差异(P<0.05);重症感染组治疗前后PCT、CRP、中性粒细胞比较存在统计学差异(P<0.05),经Spearman相关性分析,PCT与NEUT(r=0.609,P<0.05),CRP与NEUT(r=0.481,P<0.05),PCT与CRP(r=0.559,P<0.05)三指标均呈正相关性。结论:PCT、CRP联合检测对于新生儿感染性疾病的早期诊断,病情监测有重要的临床应用价值。

Objective： To study the procalcitonin （ PCT）, C - reactive protein （CRP） combined detection in the early diagnosis of neonatal infectious disease clinical application value. Methods ： PCT, CRP in 67 cases of severe infectious the neonatal （ severe infections group） , 58 cases of local infection of neonatal （localized infection group）, 32 patients with non- infectious diseases neonatal （non- infec- tion group） and 46 cases of normal newborns （control group） were examined. Differences in PCT and CRP among the groups were observed and difference between before and after therapy in severe infections group was observed. Results： There were statistical differences in serum PCT concentration among the groups （ P 〈 0.05 ） , there were statistical differences in serum CRP concentration between severe infection group and the other groups （P 〈 0.05 ）, there was no difference between local infection and non - infection group （ P 〉 0. 05 ）, compared with the normal control group there was a statistically significant difference. There were significant differences in PCT and CRP positive rate between severe infection group and the other groups （P 〈 0. 05 ）. There were significant differences in PCT, CRP, neutrophils between before and after treatment in severe infection group （ P 〈 0.05 ）. PCT and neutrophils （ r = 0. 609, P 〈 0. 05 ）, CRP and neutrophils （ r = 0. 481, P 〈 0. 05 ）, PCT and CRP （ r = 0. 559, P 〈 0. 05 ） were positively correlated by the Spearman correlation analysis. Conclusion： Combined detection of PCT, CRP in early diagnosis of neonatal infectious disease, monitoring disease has important clinical application value.