原因不明复发性流产主动免疫治疗质量控制及疗效分析

Quality control and efficacy analysis of immunothreapy for women with unexplained recurrent spontaneous abortions

目的:探讨原因不明复发性流产(URSA)主动免疫治疗质量控制以及疗效。方法:对505例URSA患者给予主动免疫治疗,于治疗前、治疗中及治疗后进行严格的质量控制,包括治疗前从业人员培训、患者基本资料的采集、适应证选择、知情同意等,治疗过程中样本采集与保存、实验室无菌操作,免疫治疗后进行疗效评估、随访。结果:经过严格的质量控制,减少了患者的不良反应;治疗中进行再次生育力的评估有利于指导妊娠。再次受孕325例,占免疫治疗人数的67.29%(325/483);未妊娠149例,占30.85%(149/483)。妊娠后加强免疫治疗并综合保胎,283例成功妊娠,占受孕总数的87.08%(283/325);42例再次流产,流产率为12.92%(42/325)。结论:URSA患者主动免疫治疗质量控制是保证疗效的有效措施。

Objective： To investigate the quality control and efficacy of lymphocyte immunotherapy （1JT） for women with unexplained recurrent spontaneous abortions. Methods： 505 women with unexplained recurrent spontaneous abortions （URSA） were immunized with lymphocytes, in the whole process of strict quality control were underwent before, during and after the treatment, including physician training, acquisition of the basic information of the patient~, the indications and informed consent before treatment. Sample eollection and preservation, laboratory aseptic technique during treatment, efficacy evaluation and follow - up after treatment were done. Results： 483 cases accepted lymphocyte immunotherapy. The side effect was reduced through strict quality control, and it was helpful to guide the pregnan- cy by fertility evaluation again during the treatment. 325 patients were again conception, the rate was 67.29% （ 325/483 ） , 149 patients were secondary infertility, the rate was 30. 85% （ 149/483 ） one year later. After pregnancy, 283 patients were suceessful pregnancy, the rate was 87. 08% （283/325） by strengthen the immune therapy and comprehensive prevent miscarriage treatment, 42 patients were abortion again, the rate was 12.92% （42/325） . Conclusion： It is the effective measures to ensure efficacy for the patients with recurrent miscar- riage by lymphocyte immunotherapy quality control.