地黄叶总苷胶囊联合肾炎康复片治疗慢性肾脏病44例疗效观察

Clinical observation of Dihuangye total glycoside capsule combined with Shenyankangfu tablets on chronic kidney disease

目的观察地黄叶总苷胶囊联合肾炎康复片治疗慢性肾脏病(CKD)的临床疗效。方法将86例CKD患者随机分为2组,治疗组44例予地黄叶总苷胶囊联合肾炎康复片治疗,对照组42例单纯予肾炎康复片治疗,2组均治疗12周。观察2组治疗前后血清肌酐(Cr)、24 h尿蛋白定量的变化,评价疗效。结果治疗组治疗后24 h尿蛋白定量低于本组治疗前及对照组治疗后(P<0.05)。治疗组总有效率77.2%,对照组总有效率66.7%,2组总有效率比较差异有统计学意义(P<0.05),治疗组疗效优于对照组。结论地黄叶总苷胶囊联合肾炎康复片对CKD患者有良好的降低24 h尿蛋白定量、改善中医证候的作用,且安全性高。

Objective To investigate the effect of Dihuangye total glycoside capsule combined with Shenyankangfu tablets on chronic kidney disease（CKD）.Methods A randomized,controlled parallel study was taken.86 patients（aged 18 to 65 year） with CKD stage 1-3 were randomly assigned to control group,which was treated by Shenyankangfu tablets and treatment group,which was treated by Dihuangye total glycoside capsule combined with Shenyankangfu tablets for 12 weeks.24 h albuminuria and serum Creatinine（Cr）,and the efficacy and side effects were assessed at the very beginning of the trials and 12th weeks later respectively.Results 24 hours urinary protein after treatment in treatment group was decreased as compared with that before treatment in treatment group and after treatment in control group（P〈0.05）.The total effective rate in treatment group（77.2%） was higher than that in control group（66.7%,P〈0.05）.Conclusion Dihuangye total glycoside capsule combined with Shenyankangfu tablets can significantly decrease 24h albuminuria,improve traditional Chinese medicine symptom on chronic kidney disease,with high safety.