摘要
运用柱层析等分离纯化方法,从蕨菜乙醇提取物的乙酸乙酯萃取部位中分离得到4个黄酮类化合物:3,4,6,2',4'-五羟基高黄烷醇(1)、槲皮素3-O-β-D-葡萄糖苷(2)、芦丁(3)、槲皮素3-O-β-D-葡萄糖苷(4),其中化合物1为新化合物,也是从蕨类植物中分离出的第一个高黄烷酮,化合物2为首次从该植物中分离得到。采用MTT法对获得的黄酮类化合物的细胞毒活性测定结果表明化合物1具有明显的细胞毒活性。
A novel homoflavonoid（1） with a homoflavanol skeletone,together with three known flavonoids： quercetin 3-O-β-D-glucopyranoside（2）,rutin（3） and kaempferol 3-O-β-D-glucopyranoside（4）,were isolated from the plant Pteridium aquilinum（L.） Kuhn（Pteridaceae）.The structure and relative stereochemistry of the new compound was elucidated as 3,4,6,2′,4′-penta hydroxyl-2,3-cis-homoflavan-3,4-trans-diol on the basis of spectroscopic analyses,including 2D-NMR spectroscopic data.This is the first reported case about homoflavane of which the ＂B＂ ring was linked with the C-2 through an additional carbon designated as C-11.The cytotoxic activity of compounds 1-4 were evaluated by MTT preliminarily.
出处
《天然产物研究与开发》
CAS
CSCD
北大核心
2013年第5期577-580,611,共5页
Natural Product Research and Development
基金
project was supported by Anhui Natural ScienceFoundation(No.090413113)
The Provincial-Level Natural Science Foundation of Anhui Education Department(KJ2009A165,KJ20108259,KJ2012A277)
onal Natural Science Foundation of China(No.81274021)
The Research Project of Lu’an City(2011LWA001)
关键词
蕨菜
3
4
6
2'
4'-五羟基高黄烷醇
高黄酮
Pteridium aquilinum（L.） Kuhn
3
4
6
2′
4′-penta hydroxyl-2
3-cis-homoflavan-3
4-trans-diol
homoflavanol
homoflavonoids
