大叶桃花心木中的柠檬苦素成分(英文)

Limonoids from the Twigs and Leaves of Swietenia macrophylla

为研究大叶桃花木(Swietenia macrophylla)的柠檬苦素类成分,采用柱层析的方法从大叶桃花心木的枝叶中分离得七个柠檬苦素分别为swimacronoid A(1)、mahonin(2)、methyl angolensate(3)、methyl 6-hydroxyango-lensate(4)、methyl 6-acetoxyangolensate(5)、swietmanin(6)、deacetylsecomahoganin(7)。其中化合物1为一个新的evodulone型的柠檬苦素,化合物7为首次从该种中分的。

To explore structural diversity of limonoids from Swietenia macrophylla,one new evodulone-type limonoid swimacronoid A（1）along with another six known limonoids,namely mahonin B（2）,methyl angolensate C（3）,methyl 6-hydroxyangolensate D（4）,methyl 6-acetoxyangolensate E（5）,swietmanin F（6）and deacetylsecomahoganin G（7）,were isolated from the 95% ethanol extract of leaves and twigs of S.macrophylla with different chromatographic methods.Among them,compound 7 was obtained from this plant for the first time.Their structures were elucidated by extensive spectroscopic techniques,including 1D,2D-NMR spectroscopy,mass spectrometry and IR.We report herein the isolation,structural elucidation of these limonoids.