清热柔肝法防治肝癌栓塞化疗后综合征的研究

Study of prevention and treatment of the syndrome after the liver cancer transcatheter arterial chemoembolization with the method of Qingre Rougan

用中药防治肝癌栓塞化疗术 (Transcatheterarterialchemoembolization,TACE或TAE)后的毒副反应。方法 :中药组44例患者在TACE后连续服用清热柔肝的中药 ;对照组46例患者在TACE后 ,当出现中度发热、高热时 ,分别予以消炎痛、复方氨基比林或地塞米松 ,观察两组TACE后毒副反应的情况。结果 :中药组高热、中热、低热的发生率分别为25 % (11/44)、36 36 % (16/44)、31 82 % (14/44) ,对照组高热、中热、低热的发生率分别为50 % (23/46)、39 13 % (18/46)、8 70 % (4/46) ,两组的发热程度比较 ,P<0 01 ,有非常显著性差异 ;中药组的重度、中度、轻度疼痛的发生率分别为0 %、4 55 % (2/44)、43 18 % (19/44) ,对照组重度、中度、轻度疼痛的发生率分别为2 17 % (1/46)、23 91 % (11/46)、39 13 % (18/46) ,两组的疼痛程度比较 ,P<0 05 ,有显著性差异 ;黄疸发生率 ,中药组为13 44 % (6/44) ,对照组为4 34 % (2/46) ,两组比较 ,P>0 05 ,无显著性差异 ;呕吐发生率 ,中药组为22 73 % (10/44) ,对照组为19 56 % (9/46) ,两组比较 ,P>0 05 ,无显著性差异。中药组未见因服用中药而引起的不良反应。结论 :清热柔肝法对TACE后的发热和疼痛 ,具有良好的防治作用。

Objective: To prevent and treat the syndrome after the liver cancer transcatheter arterial chemoembo lization (TACE) with the traditional Chinese medicine Methods: Ninety patients with the liver cancer were divided into two groups Forty four cases of the traditional Chinese medicine group (TCMG) were treated with the “Qingre Rougan”recipe after TACE, and 46 cases of the control group received imdomethacinum or amidopyrinum im or dexamethasone iv when the patient devdoped fever after TACE Results: The incidence of the high fever, medium fever and low fever in the TCMG was 25%(11/44), 36 36%(16/44)and 31 82%(14/44),respectively, while in the control group was 50%(23/46), 39 13%(18/46), 8 70%(4/46), respectively The degree of the fever between the TCMG and the control group,was significant different (P<0 01) The occurring rate of the serious pain, medium pain and mild pain in the TCMG was 0%, 4 55%(2/44)and 43 18%(19/44), respectively, however in the control group was 2 17%(1/46), 23 91%(11/46)and 39 13 %(18/46), respectively The severity of pain between the groups was different (P<0 05) The incidence of the jaundice in the TCMG and the control group was 13 44%(6/44)and 4 34%(2/46), respectively, (P>0 05) The occurring rate of vomiting in the TCMG and the control group was 22 73%(10/44)and 19 56%(9/46), respectively,(P>0 05) Conclusion: The “Qingre Rougan”recipe is effective for prevention and treatment of the syndrome after the liver cancer TACE