摘要
目的 :研究巯基修饰剂 BSO对胶质瘤细胞株 GSH含量的修饰作用及化学增敏作用。方法 :利用 Tietze还原酶法观察 BSO对体外培养的胶质瘤细胞 GSH的作用。利用 MTT法观察 BSO对胶质瘤细胞化学敏感性的影响。结果 :经 BSO作用后胶质瘤细胞的 GSH含量显著下降、化学敏感性增加。结论 :BSO能降低胶质瘤细胞的 GSH含量 。
Objective:To observe the effect of BSO on GSH content and chemosensitization of gliomacell.Methods:Use tietze methods and MTT methods to detect the effect of BSO on GSH content and chemosensitization of cultured glioma cell line SHG44.Results:BSO deplete the GSH contents of gllioma cells effecttively and the chemosensitization was raised.Conclusion:BSO is an effective chemosensitizer to glioma cell line SHG44.
出处
《山西临床医药》
2000年第7期498-500,共3页
Shanxi Clinical Medicine
