拉米夫定治疗13例乙型肝炎后肝硬化临床疗效观察

OBSERVING THE CLINICAL EFFECT OF LAMIVUDINE TREATMENT IN 13 CASES OF CIRRHOSIS AFTER HEPATITIS B

观察拉米夫定 (Lamivudine)对乙型肝炎后肝硬化的临床疗效。方法 :13例乙型肝炎后肝硬化患者给予拉米夫定口服 ,连续半年 ,观察其疗效。结果 :服药半年时HBVDNA转阴率 75 % ,ALT复常率 77%。早期肝硬化患者临床症状改善明显 ,失代偿期肝硬化患者症状改善不明显。结论 :拉米夫定对早期肝硬化有较好的临床疗效 ,且很安全 ,可以推广应用。失代偿期肝硬化患者服用拉米夫定应密切观察病情变化。

Objective:To observe the clinical effect of Lamivudine treatment in cirrhosis after hepatitis B.Methods:To observe the effect after the 13 cases received Lamivudine continuously for 6 months.Result:After 6 months treatment HBV DNA response rate was 75%,and the ALT nornalization rate was 77%.Improved symptom could be obtained in early stage of cirrhosis,but wasnt evident in advanced stage. Conclusion:The good clinical effect of Lamivudine treatment in early stage of cirrhosis could be obtained with safety. Lamivudine should be applied popularizely in treatment in the early stage of cirrhosis. The patient of advanced stage with Lamivudine should be closely observed.