卡前列腺素氨丁三醇治疗产后出血31例

Hemabate for Treating 31 Cases of Postpartum Hemorrhage

目的探讨卡前列腺素氨丁三醇(欣母沛)治疗产后出血的临床疗效及安全性。方法选择医院2011年12月至2012年10月收治产后出血的产妇62例,随机分成两组,各31例,对照组给予缩宫素20 U注射和口服米索前列醇400μg;治疗组在对照组基础上给予卡前列腺素氨丁三醇250μg肌肉注射,效果不佳者可再次注射。比较两组患者的临床疗效、治疗后各时段出血量及不良反应发生情况。结果治疗组总有效率为96.77%,明显高于对照组的83.87%(P<0.05),各时段出血量均显著少于对照组(P<0.05);治疗组在治疗过程中出现恶心呕吐3例,发热1例,面色潮红5例,胸闷1例,血压一过性升高2例,均未经处理可自行缓解。结论卡前列腺素氨丁三醇治疗产后出血疗效显著,不但起效迅速、使用方便、安全可靠,还可预防并发症的发生,值得临床推广。

Objective To investigate the clinical efficacy and safety of carboprost trometamol （hemabate） for treating postpartum hemor- rhage. Methods 62 cases of postpartum hemorrhage in our hospital from December 2011 to October 2012 were selected and randomly divided into two groups, 31 cases in each group. The control group was given oxytoein 20U by injection and oral misoprostol 400 txg; the treatment group was given hemabate 250 μg by intramuscular injection based on the basis of the control group, if the effect was not optimal, reinjection was conducted. The clinical efficacies, bleeding amounts at different time intervals after treatment and adverse re- actions were compared between the two groups. Results The total effective rate was 96.77% in the treatment group, which was signifi- cantly higher than 83.87% in the control group （P〈 0.05）; the bleeding amounts of different time intervals in the treatment group were significantly less than those in the control group with statistical difference between the two groups （P 〈 0. 05）; during the treat- ment process in the treatment group, 3 cases of nausea and vomiting, 1 case of fever, 5 cases of facial flushing, 1 case of chest pain and 2 cases of transiently increased blood pressure appeared, the symptoms all could be spontaneously alleviated without treatment. Conclusion Hemabate in the treatment of postpartum hemorrhage has significantly efficacy and rapid onset of action, is easy to use, safe and reliable, also can prevent the occurrence of complications, which deserves to be promoted and applied in clinic.