期刊文献+

舌癌转移复发相关基因分子的研究进展 被引量:2

Progress of study on metastasis and recurrence-related gene molecule of the tongue carcinoma
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摘要 舌癌的发病率位居口腔癌的首位,恶性程度较高,浸润性强,转移复发是患者死亡的主要原因。舌癌复发和转移一直是口腔颌面外科医师关注的问题,其复发转移的相关基因分子也成为最近研究的热点和难点。该文就近期文献研究的舌癌转移复发相关的基因分子作一综述。 The morbidity of tongue carcinoma is on top of oral cavity carcinoma, which has many characters including high malignancy, strong infiltration. The metastasis and recurrence is the main factors responsible for fatali-ties of tongue carcinoma patients. Metastasis and recurrence of tongue carcinoma has always been a great research hotspot of oral and maxillofacial surgeons, and its related gene molecule has also become the hot topic and difficulty in recent years. This paper reviewed metastasis and recurrence-related gene molecule of the tongue carcinoma.
出处 《中国临床新医学》 2013年第5期505-508,共4页 CHINESE JOURNAL OF NEW CLINICAL MEDICINE
基金 国家自然科学基金(编号:31060167) 广西自然科学基金(编号:桂科自0991118) 广西医疗卫生重点课题(编号:重200928)
关键词 舌癌 转移复发 基因分子 Tongue carcinoma Metastasis and recurrence Gene molecule
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参考文献25

  • 1Kusama K, Okutsu S, Takeda A, et al. p53 gene alterations and p53 protein in oral epithelial dysplasia and squamous cell carcinoma[ J]. J Pathol, 1996,178(4) :415 -421.
  • 2Scully C, Field JK, Tanzawa H. Genetic aberrations in oral or head and neck squamous cell carcinoma 3 :clinico-pathological applications [J]. Oral Oncol, 2000,36(5) :404 -413.
  • 3Kato S, Han SY, Liu W, et al. Understanding the function-structure and function-mutation relationships of p53 tumor suppressor protein by high-resolution missense mutation analysis [ J ]. Proc Natl Acad Sci USA, 2003,100(14) :8424 - 8429.
  • 4Keum KC, Chung EJ, Koom WS, et al. Predictive value of p53 and PCNA expression for occult neck metastases in patients with clinically node-negative oral tongue cancer [ J ]. Otolaryngol Head Neck Surg,2006,135 (6):858 - 864.
  • 5Hsieh JS, Lin SR, Chang MY, et al. APC, K-ras, and p53 gene mutations in colorectal cancer patients:correlation to clinicopathologic features and postoperative surveillance [ J ]. Am Surg, 2005,71 (4) : 336 - 343.
  • 6Kamb A, Gruis NA, Weaver-Feldhaus J, et al. A cell cycle regulator potentially involved in genesis of many tumor types [ J ]. Science, 1994,264(5157) :436 -440.
  • 7Nakahara Y, Shintani S, Mihara M, et al. Detection of p16 promoter methylation in the serum of oral cancer patients [ J ]. Int J Oral Maxillofac Surg,2006,35 (4) :362 - 365.
  • 8Nakazawa K, Murata S, Yuminamochi T, et al. p16 (INK4a) expression analysis as an ancillary tool for cytologic diagnosis of urothelial carcinoma [ J ]. Am J Clin Pathol,2009,132 ( 5 ) :776 - 784.
  • 9Ogawa K, Tanuma J, Hirano M, et al. Selective loss of resistant alleles at plSINK4B and pl6INK4A genes in chemically-induced rat tongue cancers[J]. Oral Oncol, 2006,42(7) :710 -717.
  • 10Sinha P, Bahadur S, Thakar A, et al. Significance of promoter hypermethylation of p16 gene for margin assessment in carcinoma tongue[ J ]. Head Neck, 2009,31 ( 11 ) :1423 - 1430.

同被引文献33

  • 1Wamakulasuriya S. Global epidcmiology of oral and oropharyngeal cancer[J]. Oral Oncol, 2009, 45(4-5): 309-16.
  • 2Cleveland JL, .lunger ML, Saraiya M, et al. The connection between human papillomavirus and oropharyngeal squamous cell carcinomas in the United States: implications for dentistry[J]. J Am Dent Assoc, 2011, 142(8): 915-24.
  • 3Dalianis T. Human papillomavirus and oropharyngeal cancer, theepidemics, and significance of additional clinical biomarkers for prediction of response to therapy[J]. Int J Oncol, 2014, 44(6): 1799-805.
  • 4Nichols AC, Faquin WC, Westra WH, et al. HPV-16 infection predicts treatment outcome in oropharyngeal squamous cell carcinoma[J]. Otolaryngol Head Neck Surg, 2009, 140(2): 228-34.
  • 5Shi W, Kato H, Perez-Ordonez B, et al. Comparative prognostic value of HPV16 E6 mRNA compared with in situ hybridization for human oropharyngeal squamous carcinoma[J]. J Clin Oneol, 2009, 27(36): 6213-21.
  • 6Weinberger PM, Yu Z, Haffty BG, et al. Molecular classification identifies a subset of human papillomavirus-associated oropharyngeal cancers with favorable prognosis[J]. J Clin Oncol, 2006, 24(5): 736-47.
  • 7Hayden J A, C6t6 P, Bombardier C. Evaluation of the quality of prognosis studies in systematic reviews[J]. Ann Intern Med, 2006, 144(6): 427-37.
  • 8McShane LM, Altman DG, Sauerbrei W, et al. Reporting recommendations for tumor marker prognostic studies (REMARK)[J]. J Natl Cancer Inst, 2005, 97(16): 1180-4.
  • 9Reimers N, Kasper HU, Weissenborn S J, et al. Combined analysis of HPV-DNA, pl6 and EGFR expression to predict prognosis in oropharyngeal cancer[J]. Int J Cancer, 2007, 120(8): 1731-8.
  • 10Preuss SF, Weinell A, Molitor M, et al. Nuclear survivin expression is associated with HPV-independent carcinogenesis and is an indicator of poor prognosis in oropharyngeal cancer[J]. Br J Cancer, 2008, 98(3): 627-32.

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