进展性脑卒中与血脂、颈内动脉斑块和狭窄的关系

Relationship between progressive stroke and blood lipids,internal carotid artery stenosis plaque

目的探讨进展性脑卒中(PS)与血脂、颈内动脉斑块和狭窄的关系。方法对85例PS及85例非PS(NPS)患者进行血总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)和高密度脂蛋白胆固醇(HDL-C)水平检测,以及颈内动脉彩色超声多普勒检查,采用多因素Logistic回归分析其对PS的影响。结果 PS组患者LDL-C水平明显高于NPS组(P<0.01),PS组颈内动脉斑块和狭窄的比率(81.2%)显著高于NPS组(22.4%)(P<0.01)。Logistic回归分析显示,LDL-C(OR=5.035)颈内动脉斑块和狭窄(OR=3.224)为PS的危险因素。结论血LDL-C水平高及颈内动脉斑块和狭窄为PS发病的危险因素。

Objective To explore the relationship between the progressive stroke （PS） and blood lipids, internal carotid artery stenosis and plaque. Methods The total cholesterol （TC）, triglycerides （TG）, low-density lipoprotein cholesterol （LDL-C） and high-density lipoprotein cholesterol （HDL-C） of 85 patients with PS and 85 patients with non-progression stroke （NPS） were examined. Internal carotid artery was examined by color ultrasound Doppler. The influences on PS were analyzed by Logistic regression analysis. Results LDL-C levelin PS group was significantly higher than that in NPS group（P%0.01） ~ The rate of internal carotid artery stenosis in PS group （75.6 %） was significantly higher than that in NPS group（42.2 % P 〈0.01）. The Logistic regression analysis showed that LDL-C （OR=5. 035） ,internal carotid artery plaque and stenosis（OR= 3. 224） were risk factors of PS. Conclusion LDL-C, internal carotid artery plaque and stenosis are important risk factors of PS.