病毒性心肌炎和室性早搏患儿血清自身抗体测定

Determination of serum autoantibodies in child patients with viral and ventricular premature complexes

目的 研究病毒性心肌炎 (VM )和室性早搏 (VPC)患儿血清抗心肌线粒体抗体和抗心磷脂抗体的改变。方法 检测了 38例VM不合并VPC (VM组 )、 31例VM合并VPC (VM +VPC组 )和 2 6例单纯室性早搏 (VPC组 )患儿 ,同时检测 40名健康儿童为正常对照组。抗体检测采用酶联免疫吸附法 (ELISA)。结果 VM组、VM +VPC组和VPC组血清抗心肌线粒体抗体的阳性率分别为 6 3 2 %、 6 4 5 %和 42 3% ,抗心磷脂抗体的阳性率分别为 47 4%、 5 1 6 %和 34 6 % ,均显著高于正常对照组。结论 VM和VPC患儿体内存在自身免疫反应 ,抗心肌线粒体抗体和抗心磷脂抗体在VM和VPC的发病中起一定作用。部分单纯室性早搏患儿也存在心肌病变。

Objective To Search for the changes of serum anti-myocardium mitochondrial antibody and anticardialipin antibody in child patients with viral (VM)and ventricular premature complexes(VPC).Methods 38 cases of VM without VPC(VM group),31 cases of VM with VPC(VM+VPC group),26 cases of simple VPC(VPC group)and 40 cases of healthy children were detected.The antibodies were detected by enzyme linked immunosorbent assay(ELISA).Results The positive rates of serum anti-myocardium mitochondrial antibody in VM,VM+VPC and VPC groups were 63 5%,64 5% and 42 3% respectively.The positive rates of anticardialipin antibody were 47 4%,51 6% and 34 6%respectively.All were significantly higher than those in control group.Conclusion There were autoimmunity reaction in VM and VPC patients.Anti-myocardium mitochondrial antibody and anticardialipin antibody had some roles in the pathogenesis of VM and VPC.There were myocardium disorders in some children with simple VPC,so positive treatments were necessary.