林州市食管癌家族聚集性分析

Study on family aggregation of esophageal cancer in Linzhou city

目的 研究林州市食管癌家族聚集性及遗传因素在食管癌发生中的作用。方法 采用以医院为基础的病例对照研究资料 ,调查了 118例食管癌新发病例及 16 8例对照的Ⅰ、Ⅱ级亲属食管癌患病情况 ,比较病例对照各级亲属食管癌发生率。用Falconer法计算遗传度。结果 病例及对照亲属食管癌患病率比较表明 ,血缘关系越近 ,亲属食管癌发生率越高。Ⅰ、Ⅱ级亲属相对危险度 (RR)分别为 3 15 (2 15～ 4 6 1)和 1 87(1 2 6～ 2 79) ,分层分析RR为 2 46 (1 87～ 3 2 3)。Ⅰ级亲属遗传度为 (5 3 39± 5 93) % ,Ⅱ级亲属为 (5 0 2 1± 10 75 ) % ,两者合并为 (5 2 2 6± 3 82 ) %。结论 林州市食管癌有明确的家族聚集性 ,遗传因素在该地食管癌的发生中具有重要的作用 ,但环境因素亦不可忽视。

Objective To investigate family aggregation of esophageal cancer (EC) in Linzhou city, a h igh risk area for EC. Methods A hospital based case-control study were conducted, wh ich included relatives of 118 EC cases and 168 controls. EC incidences in relati ves of cases and controls were compared by χ 2 test and risk ratio ( RR ) wa s calculated. Heritability ( h 2) was estimated using the Falconer method. Results EC incidence of case relatives was significantly higher than that in control relatives. The RR was 3 15 (2 15～4 61) in the firs t degree relatives and 1 87 (1 26-2 79) in the second degree relatives. The heritability was (53 39±5 93)% for the first degree relatives and (50 21±10 75)% for the second degree relatives, while the weighted h 2 was (52 26 ±3 82)%. Conclusion The genetic factor plays an important role the occu rrence of EC in Linzhou city; however, enviromental factors should not be ignore d.