不同剂量三维适形放疗对恶性肿瘤患者凝血功能的影响

Three dimensional conformal radiotherapy of different dosages on malignant tumor patients with coagulant function influence

目的探讨不同剂量三维适形放疗对恶性肿瘤患者凝血功能的影响。方法 30例恶性肿瘤患者(放疗组)行三维适形放疗,分别于放疗前及放疗20、40、60Gy时测PT、APTT、TT、FIB、D-D、PLT含量。另择健康体检者30例作为健康对照组。比较2组放疗前及放疗不同剂量时凝血指标的变化。结果与健康对照组比较,放疗组PT、APTT、TT差异无统计学意义(P>0.05),PLT、FIB、D-D显著升高(P<0.05)。与放疗前比较,放疗组放疗后PT、APTT、TT变化差异无统计学意义(P>0.05),PLT明显减少,且随剂量的增加而减少(P<0.05);D-D、FIB明显增加,且随剂量的增加而增加(P<0.05)。结论不同剂量三维适形放疗对恶性肿瘤凝血功能产生一定影响,随剂量增加凝血功能障碍越明显。

Objective To explore the three dimensional conformal radiotherapy of different dosages on malignancies patients with clotting function influence. Methods 30 cases of malignant tumors were treated with three dimensional conformal radiotherapy, were measured before radiotherapy, radiotherapy 20, 40, 60 Gy PT, ApTT,TT, FIB, D-D, PLT content. An- other 30 healthy patients were enrolled as control group. Comparison of the coagulant function indexes in two groups. Results Malignant tumor group radiotherapy after PT, APTF, and TT and before radiotherapy compared, although there were some changes, but the difference was not statistically significant （ P 〉 0.05 ）. Platelets radiotherapy after significantly reduced compared to before radiotherapy, and reduced along with increasing dosages（ P 〈 0.05 ）. D-D, the FIB radiotherapy after ob- viously increased compared to before radiotherapy, and increased along with increasing doses, the difference was statistically significant （ P 〈 0.05）. Conclusion Three dimensional conformal radiotherapy of malignant tumor different dosages of coagu- lant function produce certain effect, with the doses increased blood clotting more obviously.