^18F—FDGPET／CT显像联合血清CA125检测在复发性卵巢癌中的诊断价值

目的探讨^18F-FDG PET/CT显像联合血清CA125检测在卵巢癌术后复发的诊断价值.方法对41例怀疑复发的卵巢癌患者行PET/CT显像联合血清CA125检测,评价 PET/CT、CA125及两者联合在复发性卵巢癌中的诊断价值.结果 PET/CT显像对卵巢癌复发、转移诊断的敏感性、特异性、准确性、阳性预测值和阴性预测值分别为97.2%、80%、95.1%、97.2%、80%.血清CA125检测分别为91.7%、80%、90.2%、97.0%、57.1%.PET/CT显像联合血清CA125检测分别为100%、80%、97.6%、97.3%、100%.随着肿瘤细胞分化程度的降低,SUVmax的值也随之增高,差异有统计学意义（P〈0.05）.血清CA125≤147.3 U/ml者中单发病灶者（10/15）高于CA125〉147.3 U/ml者（6/21）,差异有统计学意义（P〈0.05）.结论18F-FDG PET/CT显像联合血清CA125检测对复发性卵巢癌的诊断具有重要临床价值.

Backgroud and purpose The aim of the study is to discuss the value of combination of 18F-FDG PET/CT and serum CA125 in the diagnosis of recurrent ovarian cancer. Methods PET/CT and CA125 tests were performed in 41 patients with suspected recurrent ovarian cancer.The practice usefulness of PET/CT and CA125 for detecting recurrent ovarian cancer has evaluated. Results The overall sensitivity,specificity,accuracy,positive and negative predictive value of PET/CT were 97.2%、80%、95.1%、97.2%、80%.The value of CA125 were 91.7%、80%、90.2%、97.0%、57.1%. The value of combination of PET/CT and serum CA125 were 100%、80%、97.6%、97.3%、100%. The present findings indicate that a significant relationship was seen between the SUVmax and the grade of differentiation in recurrent ovarian cancer（P〈0.05）.The number of single lesion in the group which serum CA125 is lower than 147.3U/ml is significant higher than the control group which serum CA125 is higher than 147.3 U/ml（P〈0.05）. Conclusion 18F-FDG PET/CT combining serum test of CA125 plays an important role in the diagnosis of recurrent ovarian cancer.