复发性淋巴瘤患者细胞免疫红细胞免疫及肿瘤标志物变化分析

目的探讨难治复发性淋巴瘤患者细胞免疫、红细胞免疫及肿瘤标志物的变化规律.方法2009年7月至2012年6月治疗的25例难治复发性淋巴瘤患者为观察组,同期的25例治疗有效患者为对照组,将两组患者的细胞免疫、红细胞免疫及肿瘤标志物水平进行检测及比较.结果观察组的CD3^＋、CD4^＋、CD4/CD8及NK均低于对照组,CD8＋高于对照组,RBC-C3bR及RFER均低于对照组,RBC-ICR及RFIR高于对照组,肿瘤标志物均高于对照组,且Ⅲ~Ⅳ期患者变化幅度均大于Ⅰ-Ⅱ期患者,差异有统计学意义（P均〈0.05）.结论难治复发性淋巴瘤患者的免疫状态较低,且肿瘤标志物水平较高.

Objective To study the variation of cellular immunity,red cell immune and tumor markers of patients with relapsed and refractory lymphoma.Methods 25 patients with relapsed and refractory lymphoma in ourhospital from July 2009 to June 2012 were selected as observation group,and 25 patients who were effectively treated at the same time were selected control group,then the cellular immunity,red cell immune and tumor markers of two groups were detected and compared. Results The CD3＋,CD4＋,CD4/CD8 and NK of observation group were lower than those of control group,CD8＋ were higher than those of control group,RBC-C3bR and RFER were lower than those of control group,RBC-ICR and RFIR were higher than those of control group,serum tumor markers were all higher than those of control group,and the those items change range of stageⅢandⅣwere bigger than those of stageⅠandⅡ,all P〈0.05,there were all significant differences. Conclusion The immune state of patients with relapsed and refractory lymphoma is lower,and their tumor markers are higher.