社区早期糖尿病肾病患者强化血糖控制研究

Study of the intensified blood sugar control for the patients with the diabetic nephropathy in their early stage in the community

目的:探讨强化血糖控制对社区早期糖尿病肾病患者的干预效果。方法:将160例社区早期糖尿病肾病患者随机分为强化组和对照组,强化组糖化血红蛋白控制在≤6.0%,对照组糖化血红蛋白≤7.0%,观察两组患者干预前后空腹血糖、糖化血红蛋白、血脂、血压及尿微量白蛋白/肌酐比值的变化。结果:两组经干预后血脂、血压均有所改善;空腹血糖、糖化血红蛋白、尿微量白蛋白/肌酐比值下降,强化组尿微量白蛋白/肌酐下降较对照组明显(P<0.05)。结论:控制早期糖尿病肾病患者饮食、血糖、血压及血脂水平能够降低尿微量白蛋白/肌酐比值,严格的血糖控制有利于延缓早期糖尿病肾病的发生发展。

Objective： To explore the intervention effect of the intensified blood sugar control of the patients with of diabetic nephropathy in their early stage in the community. Method： One hundred and sixty patients with diabetic nephropathy were randomly divided into the intensified group and control group. The glycosylated hemoglobin was controlled ≤ 6.0% in the intensified group, and ≤7.0% in the control group. The changes of fasting blood glucose, glycosylated hemoglobin, blood fat, blood pressure, urine microalbumin/creatinine were compared in the patients in the two groups before and after intervention. Result： Both blood fat and blood pressures were improved in the two groups after intervention. Fasting blood glucose, glycosylated hemoglobin, the rate of urine microalbumin/creatinine decreased. Urine microalbumin/creatinine decreased more obviously in the intensified group （P〈0.05）. Conclusion： Control of diet, blood sugar, blood pressure and blood fat of the nephropathy patients in their early stage is capable of decreasing the rate of urine microalbumin/creatinine. Strictly controlling the glycosylated hemoglobin is of benefit to prolonging the early occurrence and development of diabetic nephropathy.