双扑伪麻泡腾颗粒剂兔体内药物动力学及其相对生物利用度研究

Studies on pharmacokinetics and bioavailability of compound acetaminophen effervescent granule in rabbits

目的 :对双扑伪麻泡腾颗粒剂在兔体内的药物动力学行为进行研究。方法 :用紫外分光光度法测定家兔口服双扑伪麻泡腾颗粒剂后体内对乙酰氨基酚的血药浓度。结果 :颗粒剂比片剂吸收快 ,血药浓度高。各主要药动学参数如 Ka、Cm ax、Tmax、AU C等之间的差异均具有统计学意义。其相对生物利用度为相同处方片剂的10 8%。 结论

Objective: To study the pharmacokinetics of compound acetaminophen effervescent granule in rabbits in vivo. Method: The ultraviolet spectrophotometry was employed to determine the blood concentration of acetaminophen after oral administrating compound acetaminophen effervescent granule in rabbits. Results: Results indicated that the absorption of effervescent granule was faster than that of tablet, and the level of acetaminophen of effervescent granule was higher than that of tablet too. Results also showed that there were significant difference of the main pharmacokinetic parameters such as Ka, Tmax, Cmax, and AUC between effervescent granule and tablet. The bioavailability of effervescent granule was 1.08 times comparing to that of tablet. Conclusion: Compound acetaminophen effervescent granule was a new good dosage form of anticold.