FPA-PVP共沉淀物体内药物动力学考察

A study on pharmacokinetics of FPA PVP coprecipitate in human

目的 :通过对诺氟沙星 -聚维酮 (FPA- PVP)共沉淀物在人体内药物动力学考察 ,为临床用药提供理论参考。 方法 :采用单剂量口服给药的方式 ,采用尿药速率法求药物动力学参数。 结果 :FPA- PVP共沉淀物的相对生物利用度为 16 2 .2 6 %。 结论 :将难溶性药物制成以亲水性高分子材料为载体的共沉淀物 ,对于提高难溶性药物的生物利用度是有效的方法之一。

Objective: Pharmacokinetics of FPA PVP coprecipitate was studied in order to provide reference for clinical use. Methods: The pharmacokinetic parameters were determined with UV spectrophotometry by using urinary excretion data, following a single oral dose of 200 mg given to 7 healthy volunteers. Results: The relative bioavailability of coprecipitate was 162.26%. Conclusion: To make coprecipitate with PVP as warrier is one of the ways in order to enhance bioavailability of the difficult soluble drugs.