乳腺癌层粘连蛋白受体表达与微血管密度和转移及复发的关系

The relationship between laminin receptor expression, interstitial angiogenesis and tumor metastatic, relapse ability in breast carcinomas and their meaning

目的 :探讨乳腺癌层粘连蛋白受体 (LN R)与间质微血管密度和肿瘤转移、复发的关系及意义。方法 :应用免疫组化LSAB法检测 73例乳腺癌LN R、FⅧAg的表达 ,并对 2 8例病人进行随访分析。结果 :LN R的表达程度与乳腺癌淋巴结转移存在正相关 (P <0 0 0 0 1) ,与病理分级无关 (P >0 0 5 ) ,与乳腺癌间质微血管密度 (MVD)存在正相关 (P <0 0 0 0 1)。淋巴结转移阳性组其MVD值明显高于阴性组 (P <0 0 0 1)。随访 2 8例病人中 ,复发组的LN R表达增强比率及MVD值明显高于未复发组 (P <0 0 5 )。结论 :LN

Purpose To study the relationship between laminin receptor expression , interstitial angiogenesis and tumor metastatic, relapse ability in breast carcinomas and their meaning. Methods The expression of LN R, FⅧAg were detected in 73 cases of breast carcinoma with immunohistochemical technique, and 28 cases patients were followed up for three years. Results The expression of LN R showed positive relation with lymph node metastasis, but it was not related with pathological grade. The positive relationship had been shown between the expression degree of LN R and MVD. There was a significant difference of MVD between positive and negative groups of lymph node metastasis. The ratio of LN R expression enhancment and MVD in the relapse group was significantly higher than that in the non relapse group within the 28 cases following up patients. Conclusion Both LN R expression degree and MVD were regarded as independent factors in estimating metastasis and relapse in breast carcinoma patients.